Pokrovskaia N N
Arkh Patol. 1977;39(7):40-7.
The study of 48 cases of spleen lymphogranulomatosis showed lymphogranulomatous growths to be localized only in the periphery of lymphoid follicles. In the early stages of the disease (before the appearance of Berezovsky-Sternberg cells) of the spleen the occurrence of Hodgkin cells is specific when the diagnosis is confirmed histologically before the operation by examinations of the lymph node bioptate. Lymphogranulomatous growths in the spleen appear against the background of hyperplasia of lymphoid follicles which is most likely to be of reactive nature. Lymphogranulomatous growths in the spleen may correspond to any of 4 morphological variants of the disease (according to the classification of Lukes et al., 1966) which are its successive stages: lymphohistiocytic variant--mixed cell--lymphoid exhaustion. Similar changes of the cell composition in the granulomatous tissue occur in cases of lymphogranulomatosis with nodular sclerosis.
对48例脾脏淋巴肉芽肿病的研究表明，淋巴肉芽肿性生长仅局限于淋巴滤泡的周边。在脾脏疾病的早期阶段（在出现贝利佐夫斯基-施特恩贝格细胞之前），当通过淋巴结活检组织学检查在手术前确诊时，霍奇金细胞的出现具有特异性。脾脏中的淋巴肉芽肿性生长出现在淋巴滤泡增生的背景下，这种增生很可能是反应性的。脾脏中的淋巴肉芽肿性生长可能对应于该疾病的4种形态学变体中的任何一种（根据卢克斯等人1966年的分类），它们是疾病的连续阶段：淋巴细胞-组织细胞变体-混合细胞-淋巴细胞耗竭。在伴有结节性硬化的淋巴肉芽肿病病例中，肉芽肿组织中的细胞组成也会发生类似变化。
