Orfanos C E, Vogels L
Dermatologica. 1980;161(2):124-32.
In a controlled, randomized double-blind study, 51 patients with androgenetic alopecia and increased hair loss (telogen rate greater than 20%) were treated by local application of hair lotions with and without 17 alpha-estradiol (0.025%) for a period of at least 6 months. Before and after therapy trichograms were taken and evaluated under standardized conditions. In 63% of the treated patients a reduction of the amount of telogen hairs appeared, whereas in the control group the same reduction was found in only 37% of the cases. Similarly, in the treated group only 11% of the patients worsened, in contrast to 50% of the control group who showed an increased telogen rate (greater than 10%). The amount of growing anagen hairs and of seborrhea did not change significantly in both groups. Side effects were not seen. These findings indicate that hair lotions containing 17 alpha-estradiol may have a therapeutic value in reducing androgenetic hair loss, if applied topically for a long period of time, similar to 17 beta-estradiol. However, no regrowth of new hair was found.
在一项对照、随机双盲研究中，51名雄激素性脱发且脱发增加（休止期毛发脱落率大于20%）的患者，接受了局部涂抹含或不含17α-雌二醇（0.025%）的生发洗剂治疗，为期至少6个月。治疗前后均进行毛发显微镜检查，并在标准化条件下进行评估。在63%的接受治疗的患者中，休止期毛发数量减少，而在对照组中，只有37%的病例出现同样程度的减少。同样，治疗组中只有11%的患者病情恶化，相比之下，对照组中有50%的患者休止期毛发脱落率增加（大于10%）。两组中生长期毛发的数量和皮脂溢出情况均未发生显著变化。未观察到副作用。这些研究结果表明，长期局部应用含17α-雌二醇的生发洗剂，可能在减少雄激素性脱发方面具有治疗价值，类似于17β-雌二醇。然而，未发现有新毛发再生。
