Hertel H, Gollnick H, Matthies C, Baumann I, Orfanos C E
Universitäts-Hautklinik und Poliklinik, Freien Universität Berlin.
Hautarzt. 1989 Aug;40(8):490-5.
In a pilot study (I) the efficacy of a new combination therapy for hair loss of the diffuse type was tested in 36 patients, followed by a double blind study with 47 patients. The daily dosage was 18,000 IE retinol, 70 mg L-cystine and 7000 mg gelatin. The clinical efficacy was evaluated by standard methods, such as the preparation of trichograms and measurement of the hair density before and after treatment. The pilot study demonstrated a significant improvement, with reduction of the telogen rate by 8.3%, an increase of the anagen rate by 11%, and an increase of the hair density by 6.9%. In the double blind study (II) the trichogram showed a significant decrease of the telogen rate by 13.5% compared with pathological baseline values. There was no change in the placebo group. The lowered anagen rate of 47.2% was improved by 8%, whereas the mean value in the placebo group decreased from 47.7% to 39.9%. In addition, the percentage of dysplastic anagen hairs improved by 7.4%, as against further impairment with an increase of 26% in the placebo group. During oral therapy no systemic side-effects were detected. We conclude that long-term oral therapy with high doses of L-cystine and gelatin in combination with vitamin A may have beneficial effects on diffuse hair loss.
在一项初步研究（I）中，对36例弥漫型脱发患者测试了一种新的联合治疗方法的疗效，随后对47例患者进行了双盲研究。每日剂量为18,000国际单位视黄醇、70毫克L-胱氨酸和7000毫克明胶。通过标准方法评估临床疗效，如制作毛发图谱以及测量治疗前后的头发密度。初步研究显示有显著改善，休止期发生率降低了8.3%，生长期发生率增加了11%，头发密度增加了6.9%。在双盲研究（II）中，毛发图谱显示与病理基线值相比，休止期发生率显著降低了13.5%。安慰剂组无变化。生长期发生率降低至47.2%，改善了8%，而安慰剂组的平均值从47.7%降至39.9%。此外，发育异常的生长期毛发百分比改善了7.4%，而安慰剂组则进一步恶化，增加了26%。口服治疗期间未检测到全身性副作用。我们得出结论，高剂量L-胱氨酸和明胶联合维生素A进行长期口服治疗可能对弥漫性脱发有有益效果。
