de Zeeuw D, Donker A J, van Herk G, Kremer E
Nephron. 1978;22(4-6):366-73. doi: 10.1159/000181477.
We have investigated the influence of renal mobility on both renal blood flow and glomerular filtration, in order to evaluate its role as a potential intermediate cause of hypertension. In 25 untreated patients we compared between recumbent and upright position the relative change in the following five parameters: effective renal plasma flow (ERPF), glomerular filtration rate (GFR), renal mobility, peripheral plasma renin activity (PRA) and blood pressure. We found a positive correlation between the degree of renal mobility and an observed decrease in ERPF. On the other hand, no relation was found between the former and an observed decrease in GFR. The PRA appeared to rise following the decrease of the ERPF. These observations suggest that renal mobility adds to the orthostatic reduction in renal blood flow.
我们研究了肾脏活动度对肾血流量和肾小球滤过的影响，以评估其作为高血压潜在中间病因的作用。在25例未经治疗的患者中，我们比较了卧位和立位时以下五个参数的相对变化：有效肾血浆流量（ERPF）、肾小球滤过率（GFR）、肾脏活动度、外周血浆肾素活性（PRA）和血压。我们发现肾脏活动度与观察到的ERPF降低程度之间呈正相关。另一方面，未发现前者与观察到的GFR降低之间存在关联。随着ERPF的降低，PRA似乎升高。这些观察结果表明，肾脏活动度加剧了肾血流量的直立性减少。
