[Effectiveness of nonachlazine in ischemic heart disease under ambulatory conditions].

The efficacy of nonachlazine given in a daily dose of 90--180 mg was studied in 82 out-patients with ischemic heart disease. The drug had no marked effect on the frequency of angina pectoris attacks and the number of times that nitroglycerin had to be taken; no essential changes were noted in the pulse rate and arterial pressure level. A certain increase in the tolerance to physical loan was found. The authors emphasize that in evaluating the effect of a drug on ischemic heart disease, it is necessary to take into account the cyclic course of the disease and the effect of nonmedicamentous factors (weather changes, temporary incapacity for work, etc). The authors do not confirm the conclusion of other researchers who claim that a daily dose of 90--180 mg of nonachlazine is highly effective.