Hume K I
Sleep. 1980;2(4):417-35.
The sleep of 15 young adult subjects was polygraphically recorded before and after 8 hr phase shifts of the sleep--wakefulness rhythm in an isolation unit in which the natural cues to the time of day were absent. Following a phase delay, there was a significant increase in the amount of REM and a substantial alteration in its distribution within the sleep episodes, with the amount in the first third doubled. There were differences in the rates of adaptation among subjects, but this was generally accomplished within a week; this finding was reinforced by a similar response to a second identical shift. After a phase advance there was a significant reduction in the amount of REM and similar alterations in its distribution to those obtained after the phase delay. However, adaptation was not as clear as with the phase delay, and a further identical shift gave indications that adaptation had not been fully achieved. These results provide further evidence for a circadian rhythm of REM, with a maximum propensity in the morning, which does not adapt immediately to a sudden 8 hr phase shift of the sleep--wakefulness rhythm. However, adaptation can be achieved within a week with phase delay, while this is more difficult to detect for phase advance.
在一个没有昼夜自然线索的隔离单元中，对15名年轻成年受试者的睡眠-清醒节律进行8小时相位偏移前后的多导睡眠图记录。相位延迟后，快速眼动（REM）睡眠量显著增加，且其在各睡眠阶段的分布发生了实质性改变，前三分之一阶段的REM量增加了一倍。受试者之间的适应速度存在差异，但一般在一周内完成；对第二次相同偏移的类似反应强化了这一发现。相位提前后，REM睡眠量显著减少，其分布变化与相位延迟后相似。然而，适应情况不如相位延迟时明显，进一步相同的偏移表明尚未完全实现适应。这些结果为REM睡眠的昼夜节律提供了进一步证据，即早晨REM睡眠倾向最大，且不会立即适应睡眠-清醒节律突然的8小时相位偏移。然而，相位延迟时一周内可实现适应，而相位提前时则更难检测到适应情况。
