Burkhardt K R, Nel E E
S Afr Med J. 1980 Jun 14;57(24):981-5.
A study was undertaken to evaluate simple, reliable urine spot tests suitable for detection of the major anti-tuberculosis (TB) drugs rifampicin, isoniazid and pyrazinamide. The discrepancy between the actual ingestion of anti-TB tablets and prescribed medication was investigated in 234 hospitalized male and female patients as well as in 85 male and female outpatients with pulmonary tuberculosis. Several factors implicated in patient non-compliance are discussed, namely the degree of supervision, the independent administration of rifampicin before the other TB medication, and patient preference for certain TB medicines because of tablet size.
开展了一项研究，以评估适用于检测主要抗结核药物利福平、异烟肼和吡嗪酰胺的简单、可靠的尿斑试验。对234名住院男女患者以及85名患有肺结核的门诊男女患者，调查了抗结核药片实际服用量与处方用药量之间的差异。讨论了与患者不依从性相关的几个因素，即监督程度、在服用其他抗结核药物之前单独服用利福平，以及患者因药片大小而对某些抗结核药物的偏好。
