Cunningham-Rundles C, Pudifin D J, Armstrong D, Good R A
Vox Sang. 1980 Feb;38(2):61-7. doi: 10.1111/j.1423-0410.1980.tb02332.x.
From the Immunodeficiency Cancer Registry, it has appeared that there is an increasing frequency of neoplasia in individuals who have a selective absence of serum IgA. Approaching this question from another point of view, we have found that of 4,120 sera drawn in this cancer-oriented hospital, 12 sera had a total absence of IgA and 3 additional sera had less than 10 mg/dl. The incidence of IgA deficiency in a cancer hospital is thus 1 : 342 or 1 : 273, which is statistically similar to that previously found for other patient groups studied in the USA (average of two studies, 1 : 418), but it is substatistically increased over the incidence of IgA deficiency found in normal blood donors (average of five studies 1 : 1,677). Analysis of these sera by diagnostic categories showed that of 1,517 sera of patients with lymphoproliferative disorders, 6 were IgA deficient (frequency 1 : 253), and of 249 sera of patients with gastrointestinal neoplasm, 2 were IgA deficient (frequency 1 : 125). We conclude that, in the absence of IgA, certain organ systems, the gastrointestinal and lymphoid tissue may be at increased risk for malignant change and that the protective, anti-neoplastic role of IgA requires investigation.
免疫缺陷癌症登记处的数据显示，血清IgA选择性缺乏的个体中肿瘤形成的频率在增加。从另一个角度来看这个问题，我们发现在这家以癌症为导向的医院采集的4120份血清中，有12份血清完全缺乏IgA，另外3份血清中IgA含量低于10mg/dl。因此，癌症医院中IgA缺乏的发生率为1:342或1:273，这在统计学上与之前在美国对其他患者群体的研究结果相似（两项研究的平均值为1:418），但与正常献血者中IgA缺乏的发生率相比有统计学意义的增加（五项研究的平均值为1:1677）。按诊断类别对这些血清进行分析表明，在1517份淋巴增生性疾病患者的血清中，有6份IgA缺乏（频率为1:253），在249份胃肠道肿瘤患者的血清中，有2份IgA缺乏（频率为1:125）。我们得出结论，在缺乏IgA的情况下，某些器官系统，如胃肠道和淋巴组织，发生恶性变化的风险可能会增加，IgA的保护、抗肿瘤作用需要进一步研究。
