Crilly R G, Marshall D H, Nordin B E
Postgrad Med J. 1978;54 Suppl 2:47-9.
Fasting plasma and urinary calcium and urinary hydroxyproline are known to rise at the menopause, reflecting increased bone resorption. Oestradiol valerate and cyclic oestradiol valerate/DL-norgestrel are shown to reduce this evidence of increased bone loss. It is concluded that these preparations will be effective in preventing post-menopausal loss of bone.
已知绝经时空腹血浆及尿钙和尿羟脯氨酸会升高，这反映了骨吸收增加。已证实戊酸雌二醇及周期服用的戊酸雌二醇/炔诺孕酮能减少这种骨质流失增加的迹象。得出的结论是，这些制剂对预防绝经后骨质流失有效。
