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脂质颗粒作为膜融合过程和双层向六角形HII相转变中的一种中间结构。

The lipidic particle as an intermediate structure in membrane fusion processes and bilayer to hexagonal HII transitions.

作者信息

Verkleij A J, van Echteld C J, Gerritsen W J, Cullis P R, de Kruijff B

出版信息

Biochim Biophys Acta. 1980 Aug 14;600(3):620-4. doi: 10.1016/0005-2736(80)90465-4.

DOI:10.1016/0005-2736(80)90465-4
PMID:7407134
Abstract

Small unilamellar vesicles comprised of a mixture of phosphatidylethanolamine/phosphatidylcholine/cholesterol (3 : 1 : 2) fuse to form large multilamellar vesicles on increasing the temperature from 0 to 50 degrees C. This event is associated with the appearance of lipidic particles at the fusion sites, consistent with a role as intermediary structures during the fusion process. Further, for phosphatidylcholine/cardiolipin (1 : 1) liposomes in the presence of Mn2+ a direct relationship between lipidic particles and the hexagonal (HII) phase is demonstrated which suggests that lipidic particles can also occur as intermediaries between bilayer and hexagonal (HII) structures.

摘要

由磷脂酰乙醇胺/磷脂酰胆碱/胆固醇（3:1:2）混合物构成的小单层囊泡，在温度从0℃升高到50℃时会融合形成大的多层囊泡。这一过程与融合位点处脂质颗粒的出现有关，这与脂质颗粒在融合过程中作为中间结构的作用一致。此外，对于在Mn2+存在下的磷脂酰胆碱/心磷脂（1:1）脂质体，已证明脂质颗粒与六方（HII）相之间存在直接关系，这表明脂质颗粒也可以作为双层结构和六方（HII）结构之间的中间体出现。

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The lipidic particle as an intermediate structure in membrane fusion processes and bilayer to hexagonal HII transitions.脂质颗粒作为膜融合过程和双层向六角形HII相转变中的一种中间结构。
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