Willer J C, Albe-Fessard D
Brain Res. 1980 Oct 6;198(2):419-26. doi: 10.1016/0006-8993(80)90755-6.
The effects of a repetitive stress induced by anticipation of pain were studied on the following somato-vegetative parameters: monosynaptic reflex (H reflex), nociceptive flexion reflex (RIII reflex), heart rate and respiratory frequency, in normal trained volunteers. A progressive increase in heart rate and in respiratory frequency, as well as a facilitation in H reflex parallel to an inhibition of RIII reflex (threshold increased) were observed in all subjects as a function of repetition of stress during 45 min. At this moment, a double-blind injection of a strong dose of naloxone (4 mg) resulted in a rapid exacerbation in vegetative responses (tachycardia, polypnea) as well as in an increase in the facilitation of the H reflex, whereas the RIII reflex was dramatically facilitated (threshold decreased). In contrast, no significant change in these parameters was observed during placebo (saline) injection compared to a control situation (no injection). These data strongly suggest that endogenous opioids are involved in the phenomenon of stress-induced analgesia in man. Moreover, they show that the release of opiates in these conditions possibly modulates non-specific structures which are known to be activated during stress or emotion.
在正常训练的志愿者中，研究了预期疼痛引起的重复性应激对以下躯体-植物神经参数的影响：单突触反射（H反射）、伤害性屈曲反射（RIII反射）、心率和呼吸频率。在45分钟内，随着应激的重复，所有受试者的心率和呼吸频率逐渐增加，同时H反射增强，RIII反射受到抑制（阈值升高）。此时，双盲注射大剂量纳洛酮（4毫克）导致植物神经反应迅速加剧（心动过速、呼吸急促），H反射的增强也增加，而RIII反射则显著增强（阈值降低）。相比之下，与对照情况（未注射）相比，安慰剂（生理盐水）注射期间这些参数没有显著变化。这些数据有力地表明内源性阿片类物质参与了人类应激诱导镇痛现象。此外，它们表明在这些情况下阿片类物质的释放可能调节了已知在应激或情绪期间被激活的非特异性结构。
