Chattopadhyay Pronobesh, Upadhyay Aadesh, Agnihotri Amit, Karmakar Sanjeev, Ghoyary Danswerang, Veer Vijay
Defence Research Laboratory, Tezpur, Assam, India.
Toxicol Int. 2013 Jan;20(1):25-9. doi: 10.4103/0971-6580.111552.
Mycotoxins are fungal toxin and contaminated to human through food-stuffs. Hematological abnormality, mainly thrombocytopenia and leukopenia are induced after consumption of mycotoxin. Experiments were conducted to evaluate the hematotoxicity of trichothecenes mycotoxins in Sprague-Dawley rats. Hematological parameters viz. Hemoglobin, hematocrit, erythrocyte count (RBC), white blood cell count (WBC), lymphocytes, monocytes, neutrophils, eosinophils, basophils, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red blood cell distribution width, mean platelet volume, plateletcrit and platelet distribution width were determined at 0, 6, 12 and 24 h after injection of 0.5 ml of T-2, Deoxynivalenol (DON), nivalenol, zearalenone, neosolaniol, ochratoxin-B mycotoxin equivalent to 1 × 10(-3) μg/μl to Sprague-Dawley rats. Experiments showed that trichothecenes toxin produces severe hematological alternation. The reductions of RBC and WBC were observed in all Fusarium mycotoxins treated group. T-2 toxin group shows severe toxicity as compared to other mycotoxin treated group. DON is the least hematotoxicity and T-2 the most.
霉菌毒素是真菌毒素，可通过食品污染人类。食用霉菌毒素后会引发血液学异常，主要是血小板减少和白细胞减少。进行实验以评估单端孢霉烯族霉菌毒素对斯普拉格-道利大鼠的血液毒性。在给斯普拉格-道利大鼠注射0.5毫升相当于1×10(-3)微克/微升的T-2毒素、脱氧雪腐镰刀菌烯醇（DON）、雪腐镰刀菌烯醇、玉米赤霉烯酮、新茄病镰刀菌烯醇、赭曲霉毒素B霉菌毒素后的0、6、12和24小时，测定血液学参数，即血红蛋白、血细胞比容、红细胞计数（RBC）、白细胞计数（WBC）、淋巴细胞、单核细胞、中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞、平均红细胞体积、平均红细胞血红蛋白、平均红细胞血红蛋白浓度、红细胞分布宽度、平均血小板体积、血小板压积和血小板分布宽度。实验表明，单端孢霉烯族毒素会产生严重的血液学变化。在所有镰刀菌霉菌毒素处理组中均观察到红细胞和白细胞减少。与其他霉菌毒素处理组相比，T-2毒素组显示出严重毒性。DON的血液毒性最小，T-2的血液毒性最大。
