Platt M R, Mills L J, Estrera A S, Hillis L D, Buja L M, Willerson J T
Circulation. 1980 Oct;62(4):862-9. doi: 10.1161/01.cir.62.4.862.
Prosthetic valvular dysfunction resulting in clinically significant complications occurred in six patients with Hancock porcine heterografts. In one patient with a prosthetic valve in the aortic position, massive prosthetic thrombosis resulted in sudden death. In two patients who had a mitral prosthesis, thrombosis resulted in congestive heart failure and systemic embolization; in one of the latter patients, the thrombi were infected with Candida sp. Calcification of organizing thrombi and cusp tissue resulted in valvular stenosis and congestive heart failure in one patient with an aortic prosthesis and in two patients with mitral prostheses. Four of the six patients died. The prosthetic valves had been in place for 6 months to 3 years before onset of complications. During the same 4-year interval, over 400 porcine prosthese were inserted. This report provides further clarification of the nature and frequency of clinical complications related to degeneration and thrombosis of Hancock porcine heterograft valves.
6例植入Hancock猪异种瓣膜的患者出现了导致具有临床意义并发症的人工瓣膜功能障碍。1例主动脉位人工瓣膜患者发生大量人工瓣膜血栓形成，导致猝死。2例二尖瓣人工瓣膜患者发生血栓形成，导致充血性心力衰竭和全身栓塞；其中1例患者的血栓被念珠菌属感染。1例主动脉人工瓣膜患者和2例二尖瓣人工瓣膜患者因机化血栓和瓣叶组织钙化导致瓣膜狭窄和充血性心力衰竭。6例患者中有4例死亡。并发症出现前，人工瓣膜已植入6个月至3年。在同一4年期间，植入了400多个猪瓣膜。本报告进一步阐明了与Hancock猪异种移植瓣膜退变和血栓形成相关的临床并发症的性质和发生率。
