González-Barón S, Bogas A M, Molina M, García-Matilla F
Rev Esp Fisiol. 1978 Dec;34(4):453-62.
Larynx resistance changes during the respiratory cycle at rest and after mechanical stimulation of the epithelium on different zones of the upper airways (extrathoracic trachea, glottis, nasopharynx) were studied in the dog by isolated glottis in situ technique. In reposed breathing, the increase in larynx resistance always started when inspiratory airflow reached its maximum value. Resistance remained high during expiration and had its lowest value when expiratory airflow decreased towards zero. The electromyogram reading for the abdominal muscle evinced low or no activity during the smaller larynx resistance period. The extrathoracic trachea mechanical stimulation with cough response was determined by a significant decrease of larynx resistance. There was also a significant increase in expiratory airflow and abdominal pressure. Inspiratory and expiratory total lung resistance values were both significantly increased with regard to reposed breathing. Mechanical larynx stimulation determined reflexive closing of the glottis, expiratory apnea, minimal abdominal pressure. No potentials were formed in the expiratory abdominal electromyogram. The response was similar to a spontaneous swallowing. Larynx resistance reached its minimal value before the expiratory airflow reached zero. Mechanical nasopharyngeal stimulation significantly increased larynx resistance.
采用原位孤立声门技术,在犬身上研究了静息呼吸周期以及对上呼吸道不同区域(胸外气管、声门、鼻咽)的上皮进行机械刺激后喉阻力的变化。在静息呼吸时,喉阻力的增加总是在吸气气流达到最大值时开始。呼气时阻力保持较高水平,而当呼气气流降至零时阻力达到最低值。在喉阻力较小的时期,腹肌的肌电图读数显示活动较低或无活动。胸外气管机械刺激引发咳嗽反应时,喉阻力显著降低。呼气气流和腹压也显著增加。与静息呼吸相比,吸气和呼气时的总肺阻力值均显著增加。机械性喉刺激可导致声门反射性关闭、呼气性呼吸暂停、腹压最小。呼气时腹肌肌电图未形成电位。该反应类似于自发吞咽。在呼气气流降至零之前,喉阻力达到最小值。机械性鼻咽刺激显著增加喉阻力。