Wallace J E, Krauter E E, Campbell B A
J Gerontol. 1980 May;35(3):355-63. doi: 10.1093/geronj/35.3.355.
Short-term and spatial memory were studied in Fischer 344 rats ranging in age from 6 to 26 months of age. Spatial memory, as measured by performance in an 8-armed radial maze, declined gradually with age. In contrast, short-term memory, as measured by retention of previous choices in the spatial maze over short intervals and performance on a modified form of Konorski's discriminated delayed response task, did not decline differentially as a function of age. These findings may be comparable to those obtained in the aged human, who also show marked deficits in spatial memory and little change in primary memory under appropriate test conditions.
对6至26月龄的Fischer 344大鼠的短期记忆和空间记忆进行了研究。通过在八臂放射状迷宫中的表现来衡量的空间记忆，随年龄逐渐下降。相比之下，通过在短时间间隔内空间迷宫中对先前选择的保持以及在改良形式的科诺尔斯基辨别延迟反应任务中的表现来衡量的短期记忆，并未随年龄出现差异下降。这些发现可能与在老年人类中获得的发现相似，在适当的测试条件下，老年人类在空间记忆方面也表现出明显缺陷，而初级记忆变化不大。
