Zajicek G
Med Hypotheses. 1980 May;6(5):447-53. doi: 10.1016/0306-9877(80)90097-3.
The reevaluation of previously reported studies in carcinogenesis indicates the existence of a mechanism which protects mice from the carcinogenic hazard, Mice had been subjected to ultraviolet radiation (U.V.), applied at regular doses and intervals (10). The time from the first application to the appearance of a 100 mm3 sized tumor was defined as "development time" td. The td times had been found to be distributed lognormally. Such a distribution indicates that the magnitude of td is proportional to the carcinogenic exposure which means that the longer a mouse is exposed to U.V. the slower the progression of its neoplasms. This may be evident also from the lognormal risk function or conditional failure rate lambda (td) which initially rises in these animals to a maximum, whereupon it declines. The declining risk function supports the existence of a protective mechanism in the body which withstands carcinogenesis.
对先前报道的致癌作用研究的重新评估表明，存在一种保护小鼠免受致癌危害的机制。小鼠接受了以固定剂量和间隔施加的紫外线辐射（U.V.）（10）。从首次施加到出现100立方毫米大小肿瘤的时间定义为“发展时间”td。已发现td时间呈对数正态分布。这种分布表明td的大小与致癌暴露成正比，这意味着小鼠暴露于紫外线的时间越长，其肿瘤进展越慢。这也可能从对数正态风险函数或条件失效率λ（td）中明显看出，该函数最初在这些动物中上升到最大值，随后下降。下降的风险函数支持体内存在一种抵抗致癌作用的保护机制。
