de Gruijl F R, Forbes P D
Dept of Dermatology, Utrecht University, University Hospital, The Netherlands.
Bioessays. 1995 Jul;17(7):651-60. doi: 10.1002/bies.950170711.
Ultraviolet (UV) radiation is a very common carcinogen in our environment, but epidemiological data on the relationship between skin cancers and ambient solar UV radiation are very restricted. In hairless mice the process of UV carcinogenesis can be studied in depth. Experiments with this animal model have yielded quantitative data on how tumor development depends on dose, time and wavelength of the UV radiation. In combination with epidemiological data, these experimental results can be transposed to humans. Comparative studies on molecular, cellular and physiological changes in mouse and man can further our fundamental understanding of UV carcinogenesis in man. This is likely to improve risk assessments such as those related to stratospheric ozone depletion, and to yield well-targeted intervention schemes, e.g. prescribing a specific drug or diet, for high-risk individuals.
紫外线（UV）辐射是我们环境中一种非常常见的致癌物，但关于皮肤癌与环境太阳紫外线辐射之间关系的流行病学数据非常有限。在无毛小鼠中，可以深入研究紫外线致癌过程。使用这种动物模型进行的实验已经得出了关于肿瘤发展如何取决于紫外线辐射的剂量、时间和波长的定量数据。结合流行病学数据，这些实验结果可以应用于人类。对小鼠和人类分子、细胞和生理变化的比较研究可以加深我们对人类紫外线致癌作用的基本理解。这可能会改善风险评估，例如与平流层臭氧消耗相关的风险评估，并产生针对性强的干预方案，例如为高危个体开特定的药物或饮食处方。
