Ohlin H, Jerntorp P, Bergström B, Almér L O
Br Med J (Clin Res Ed). 1982 Sep 25;285(6345):838-40. doi: 10.1136/bmj.285.6345.838.
Many diabetics who take chlorpropamide (a sulphonylurea compound) experience facial flushing after drinking even small amounts of alcohol. These flushers have a noticeably lower prevalence of late complications of diabetes (microangiopathy, macroangiopathy, and neuropathy) than non-flushers. This flush reaction is accompanied by increased blood acetaldehyde concentrations, suggesting an inhibition of aldehyde dehydrogenase activity. In the present study the activity of this enzyme in erythrocytes was assessed in the absence of chlorpropamide. Erythrocyte homogenates obtained from flushers and non-flushers were incubated with acetaldehyde and the rate of metabolism studies. Flushers eliminated acetaldehyde more slowly at a low range of concentrations (0--30 mumol/l), suggesting a difference in aldehyde dehydrogenase activity. Further studies are needed to clarify the role of this enzyme in the pathogenesis of diabetic complications.
许多服用氯磺丙脲（一种磺酰脲类化合物）的糖尿病患者即使饮用少量酒精也会出现面部潮红。与不出现潮红的患者相比，这些出现潮红的患者糖尿病晚期并发症（微血管病变、大血管病变和神经病变）的患病率明显更低。这种潮红反应伴随着血液中乙醛浓度的升高，提示醛脱氢酶活性受到抑制。在本研究中，在不存在氯磺丙脲的情况下评估了该酶在红细胞中的活性。从出现潮红者和不出现潮红者获取的红细胞匀浆与乙醛一起孵育，并进行代谢速率研究。在低浓度范围（0 - 30 μmol/L）时，出现潮红者消除乙醛的速度更慢，这表明醛脱氢酶活性存在差异。需要进一步研究以阐明该酶在糖尿病并发症发病机制中的作用。
