Vickery B H, McRae G I, Kent J S, Tomlinson R V
Prostaglandins Med. 1980 Aug;5(2):93-100. doi: 10.1016/0161-4630(80)90096-8.
Beagle bitches were treated on days 20-22 of pregnancy with TPT as an aqueous solution administered subcutaneously via a minipump at a rate of 10 micrograms per hour for either 24 (I) or 48 hours (II). Additional animals received a single subcutaneous injection of 200 micrograms of TPT as an aqueous solution (III) or dissolved in polyethylene glycol 400 (IV) or the methyl ester of TPT dissolved in polyethylene glycol 400 (V). The duration of action was assessed by the nadir in circulating progesterone levels. By this criterion the duration of action in the different groups ranked I=III<II=IV<V, the nadir occurring at 2, 3 and 3-4 days post treatment, respectively. Duration of action correlated with the incidence of abortion. Salivation, emesis and diarrhea or hypothermia side effects, previously noted for this agent, were not affected by the manipulations of duration of action.
在妊娠第20 - 22天，对雌性比格犬进行三苯氧胺（TPT）处理，以水溶液形式通过微型泵皮下给药，给药速度为每小时10微克，持续24小时（I组）或48小时（II组）。另外的动物接受单次皮下注射200微克TPT水溶液（III组），或溶于聚乙二醇400的TPT（IV组），或溶于聚乙二醇400的TPT甲酯（V组）。通过循环孕酮水平的最低点评估作用持续时间。根据这一标准，不同组的作用持续时间排序为I = III < II = IV < V，最低点分别出现在治疗后2天、3天和3 - 4天。作用持续时间与流产发生率相关。此前该药物出现的流涎、呕吐、腹泻或体温过低等副作用，不受作用持续时间操作的影响。
