Cameron I T, Baird D T
Contraception. 1986 Feb;33(2):121-5. doi: 10.1016/0010-7824(86)90078-8.
The termination of early pregnancy (less than 56 days amenorrhoea) has been investigated using 16,16-dimethyl-trans-delta 2-PGE, methyl ester in a controlled release preparation. The onset of crampy abdominal pain was seen after 270 +/- 39 minutes and bleeding occurred after 603 +/- 95 minutes. Two (15%) patients required no pain relief during treatment, however 5 (38%) requested oral analgesia, and in 6 (46%) individuals the pain was severe enough to warrant parenteral opiates. The overall success rate for complete abortion was 85%. No serious adverse effects were seen, but vomiting occurred in 2 (15%) women, and diarrhoea in 3 (23%). Although the use of this prostaglandin analogue in slow release form provides an effective treatment method for early abortion using a reduced total dose of prostaglandin, the acceptability of the drug as an agent for menstrual induction continues to be limited by the occurrence of troublesome gastro-intestinal side effects.
使用控释制剂中的16,16 - 二甲基 - 反式 - δ2 - PGE甲酯对早期妊娠（闭经少于56天）的终止进行了研究。在270±39分钟后出现痉挛性腹痛，在603±95分钟后出现出血。两名（15%）患者在治疗期间无需止痛，然而5名（38%）患者要求口服镇痛，6名（46%）患者的疼痛严重到需要注射阿片类药物。完全流产的总体成功率为85%。未观察到严重不良反应，但2名（15%）女性出现呕吐，3名（23%）出现腹泻。尽管以缓释形式使用这种前列腺素类似物可通过减少前列腺素的总剂量为早期流产提供一种有效的治疗方法，但该药物作为月经诱导剂的可接受性仍然受到令人烦恼的胃肠道副作用的限制。
