Coggins C R, Fouillet X L, Lam R, Morgan K T
Toxicology. 1980;16(2):83-101. doi: 10.1016/0300-483x(80)90040-2.
Changes in the rat respiratory tract produced by a 12-week exposure to the particulate or vapour phases of cigarette smoke are described and compared with the changes produced by combined exposure to both phases. The most extensive changge in the upper respiratory tract was a pronounced squamous metaplasia of the laryngeal epithelium, along with extensive deciliation and squame cell production. In the lung, smoke exposure produced marked increase in the numbers of bronchial goblet cells and intra-alveolar brown-gold macrophages. None of the above changes could be directly attributed to exposure to vapour phase alone, and in many cases the lesions produced by whole smoke and by carbon filtered smoke were directly comparable. For lesions to occur in some ciliated areas of the tract both phases of the smoke were required.
描述了大鼠暴露于香烟烟雾颗粒或气相中12周后呼吸道产生的变化，并将其与同时暴露于两相产生的变化进行了比较。上呼吸道最广泛的变化是喉上皮明显的鳞状化生，伴有广泛的脱纤毛和鳞状细胞产生。在肺部，烟雾暴露使支气管杯状细胞和肺泡内棕金巨噬细胞数量显著增加。上述变化均不能直接归因于单独暴露于气相，在许多情况下，全烟雾和碳过滤烟雾产生的病变直接具有可比性。呼吸道某些纤毛区域出现病变需要烟雾的两相都存在。
