Johansson B B
Stroke. 1978 Nov-Dec;9(6):588-90. doi: 10.1161/01.str.9.6.588.
Conscious rats and rats under nitrous oxide anesthesia were subjected to blood pressure elevations by injection of epinephrine, bicuculline and amphetamine. Mean arterial pressure was measured from a chronic indwelling cannula in the aorta in awake rats. The protein leakage in the brains was studied using Evans blue and 125IHSA. Conscious animals developed less blood-brain barrier dysfunction than anesthetized ones. The largest difference was obtained with amphetamine and the smallest with epinephrine. Possible explanations to the results are discussed.
清醒大鼠和一氧化二氮麻醉下的大鼠通过注射肾上腺素、荷包牡丹碱和苯丙胺使血压升高。在清醒大鼠中，通过主动脉内的慢性留置插管测量平均动脉压。使用伊文思蓝和125I标记的人血清白蛋白研究脑内蛋白质渗漏情况。清醒动物比麻醉动物发生的血脑屏障功能障碍更少。使用苯丙胺时差异最大，使用肾上腺素时差异最小。文中讨论了这些结果可能的解释。
