Rubin M E, Sayed H I, Bowman J M
Vox Sang. 1980;38(4):185-90. doi: 10.1111/j.1423-0410.1980.tb02351.x.
Five tetanus toxoids of different manufacture and of different concentrations were used to determine the most effective formulation and strength of toxoid for the production in human volunteers of sustained high levels of tetanus antitoxin suitable for the production of human tetanus immune globulin. The most satisfactory results were obtained with a fluid, low-protein, column-purified tetanus toxoid. 79% of volunteers injected with a 36 Lf dose of this material achieved antitoxin levels of greater than or equal to 10 antitoxin units/ml. The mean duration of these levels was 125 days.
使用了五种不同生产厂家、不同浓度的破伤风类毒素，以确定能在人体志愿者中产生适合生产人破伤风免疫球蛋白的持续高水平破伤风抗毒素的最有效类毒素配方和强度。使用一种液体、低蛋白、柱纯化的破伤风类毒素获得了最满意的结果。注射36Lf剂量该材料的志愿者中，79%的人抗毒素水平达到或高于10抗毒素单位/毫升。这些水平的平均持续时间为125天。
