Galasko C S, Edwards D H, Fearn C B, Barber H M
Acta Orthop Scand. 1976 Jun;47(3):276-82. doi: 10.3109/17453677608991991.
One hundred and ten female patients, over the age of 60, with intertrochanteric or transcervical fractures were included in a controlled, randomized, clinical trial investigating the value of low dosage heparin in the prophylaxis of deep vein thrombosis. There were 50 completed pairs. Eight (16 per cent) deep vein thromboses occurred in the heparinized group compared with 23 (46 per cent) deep vein thromboses in the control group. The incidence of pulmonary embolism was also reduced. The diagnosis of deep vein thrombosis was made on clinical grounds, supplemented by phlebography and autopsy. There was no difference in the wound hematoma or infection rate. The heparin was commenced on admission to hospital and it is suggested that in this group of patients low dosage heparin prophylaxis should start on admission and not wait until surgery.
110名60岁以上患有转子间或经颈骨折的女性患者被纳入一项对照、随机临床试验，该试验旨在研究低剂量肝素在预防深静脉血栓形成方面的价值。共有50对配对完成。肝素化组发生8例（16%）深静脉血栓，而对照组发生23例（46%）深静脉血栓。肺栓塞的发生率也有所降低。深静脉血栓形成的诊断基于临床依据，并辅以静脉造影和尸检。伤口血肿或感染率没有差异。肝素在入院时开始使用，建议在这类患者中，低剂量肝素预防应在入院时开始，而不是等到手术时。
