Kimura S, Nishikawa T
Arch Dermatol Res. 1980;268(1):79-84. doi: 10.1007/BF00403889.
To clarify the mechanism underlying the deposition of plasma protein in the psoriatic horny layer, extracts of psoriasis scale treated with fibrinolysin and acid citrate buffer were examined using electrophoresis and immunoelectrophoresis. Each extract showed electrophoretic and immunoelectrophoretic pattern similar to that of normal human serum, although the albumin-glublin ratio was lower than that of normal human serum. Extract after fibrinolysin treatment showed larger amount of substances than that after acid citrate buffer treatment. In each extract, high concentrations of fibrin-degrated products were found; fibrinogen was absent. These findings suggest that in the main mechanism of the deposition of plasma protein nonimmunological processes are involved, as revealed by our previous study with an immunohistochemical method, and that some fibrinolytic process occurs in psoriatic lesions.
为阐明银屑病角质层中血浆蛋白沉积的潜在机制，使用电泳和免疫电泳对用纤维蛋白溶酶和枸橼酸缓冲液处理过的银屑病鳞屑提取物进行了检测。尽管白蛋白与球蛋白的比例低于正常人血清，但每种提取物均显示出与正常人血清相似的电泳和免疫电泳图谱。纤维蛋白溶酶处理后的提取物显示出比枸橼酸缓冲液处理后的提取物含有更多的物质。在每种提取物中，均发现高浓度的纤维蛋白降解产物；未发现纤维蛋白原。这些发现表明，正如我们之前用免疫组织化学方法研究所揭示的，血浆蛋白沉积的主要机制涉及非免疫过程，并且银屑病皮损中发生了一些纤维蛋白溶解过程。
