A further study on the mechanism of deposition of plasma protein in psoriasis scale.

To clarify the mechanism underlying the deposition of plasma protein in the psoriatic horny layer, extracts of psoriasis scale treated with fibrinolysin and acid citrate buffer were examined using electrophoresis and immunoelectrophoresis. Each extract showed electrophoretic and immunoelectrophoretic pattern similar to that of normal human serum, although the albumin-glublin ratio was lower than that of normal human serum. Extract after fibrinolysin treatment showed larger amount of substances than that after acid citrate buffer treatment. In each extract, high concentrations of fibrin-degrated products were found; fibrinogen was absent. These findings suggest that in the main mechanism of the deposition of plasma protein nonimmunological processes are involved, as revealed by our previous study with an immunohistochemical method, and that some fibrinolytic process occurs in psoriatic lesions.