Sonty S, Schwartz B
Arch Ophthalmol. 1980 Aug;98(8):1422-6. doi: 10.1001/archopht.1980.01020040274012.
The two-point fluorophotometry technique was used to analyze quantitatively absolute fluorescein filling defects or hypofluorescent areas in glaucomatous optic discs. Significant differences were found between hypofluorescent and normal fluorescent areas. The hypofluorescent areas had slower and lesser filling of fluorescein and a slower disappearance of fluorescein compared with normal fluorescent areas. Also, the hypofluorescent areas showed a slow and persistent accumulation of fluorescein. Age, blood pressure, ocular pressure, and percent area of optic disc pallor were significantly correlated with changes in the circulation in the areas of normal fluorescence and hypofluorescence. This study suggests a decreased blood flow and a smaller vascular bed together with narrower vessels and increased permeability of the vessels in the hypofluorescent areas.
采用两点荧光光度测定技术对青光眼视盘中的绝对荧光素充盈缺损或低荧光区进行定量分析。发现低荧光区与正常荧光区之间存在显著差异。与正常荧光区相比，低荧光区荧光素的充盈速度较慢、充盈量较少，荧光素的消失速度也较慢。此外，低荧光区还显示出荧光素的缓慢且持续积累。年龄、血压、眼压和视盘苍白面积百分比与正常荧光区和低荧光区的循环变化显著相关。本研究提示低荧光区血流量减少、血管床较小，同时血管变窄且血管通透性增加。
