Schwartz B, Rieser J C, Fishbein S L
Arch Ophthalmol. 1977 Nov;95(11):1961-74. doi: 10.1001/archopht.1977.04450110055002.
An improved technique for high-contast, high-resolution fluorescein angiography of the optic disc has been developed that almost eliminates pseudofluorescence. Fluorescein angiography of the optic disc was performed on normal, ocular hypertensive, and glaucomatous patients. Rapid-sequence angiograms in the early arterial phases have demonstrated localized areas of hypofluorescence or filling defects of the optic disc. Two types of fluorescein filling defects were observed-absolute and relative. The number of absolute filling defects, which increased with degree of visual field loss, was greater in glaucomatous than in ocular hypertensive or normal eyes. Similarly, ocular hypertensive eyes showed a larger number of discs with filling defects than normal eyes. It is postulated that relative defects progress to absolute filling defects, which may be an indication of impending loss of visual field.
一种用于视盘高对比度、高分辨率荧光素血管造影的改进技术已被开发出来，该技术几乎消除了假荧光。对正常、高眼压和青光眼患者进行了视盘荧光素血管造影。早期动脉相的快速序列血管造影显示视盘存在局部低荧光区或充盈缺损。观察到两种类型的荧光素充盈缺损——绝对缺损和相对缺损。绝对充盈缺损的数量随视野缺损程度增加，青光眼患者比高眼压或正常眼更多。同样，高眼压眼比正常眼有更多视盘存在充盈缺损。据推测，相对缺损会发展为绝对充盈缺损，这可能预示着即将出现视野缺损。
