Shagass C, Roemer R A, Straumanis J J, Amadeo M
Biol Psychiatry. 1980 Apr;15(2):183-207.
This study investigated differences in evoked potential (EP) topography between psychotic depressives, nonpatient controls, chronic schizophrenics, and neurotic depressives. Somatosensory (SEP), visual, and auditory EPs were recorded from 14 scalp leads. Locations (latencies) of consecutive EP peaks in a given subject were identified visually in key leads; these latencies were used for computer measurements of amplitude in all leads. Four sets of age- and sex-matched groups were compared by multivariate profile analysis. Amplitude differences between groups agreed well with findings obtained by comparing group sum EPs, indicating convergence between the two measurement methods. Topographic differences involved mainly SEP peaks. Distributions of SEP peaks P90 (positivity at 90 msec), N130, and P290 showed more posterior maxima in psychotic depressives than controls, while P185 was maximal more anteriorly in depressives. Distribution of SEP peaks N20, N60, N130, and P185 differed between psychotic depressives and chronic schizophrenics. The topographic approach appears to provide new EP information of pyschiatric relevance.
本研究调查了精神病性抑郁症患者、非患者对照、慢性精神分裂症患者和神经症性抑郁症患者之间诱发电位（EP）地形图的差异。从14个头皮导联记录体感诱发电位（SEP）、视觉诱发电位和听觉诱发电位。在关键导联中通过视觉识别给定受试者连续EP波峰的位置（潜伏期）；这些潜伏期用于计算机测量所有导联中的波幅。通过多变量轮廓分析比较了四组年龄和性别匹配的组。组间波幅差异与通过比较组总EP获得的结果非常一致，表明两种测量方法之间具有趋同性。地形图差异主要涉及SEP波峰。SEP波峰P90（90毫秒时的正向波）、N130和P290的分布在精神病性抑郁症患者中比对照组显示出更多的后位最大值，而P185在抑郁症患者中在前位更明显。精神病性抑郁症患者和慢性精神分裂症患者之间SEP波峰N20、N60、N130和P185的分布不同。地形图方法似乎提供了与精神病学相关的新的EP信息。
