Shagass C, Straumanis J J, Roemer R A, Amadeo M
Biol Psychiatry. 1977 Apr;12(2):221-35.
This is the initial report of results obtained by a comprehensive approach to investigation of evoked potential (EP) characteristics of psychiatric patients. EP to left and right medion nerve, visual (checkerboard flash), and auditory (click) stimuli were obtained for 14 monopolar scalp and one EOG derivation in 32 schizophrenics and 16 nonpatients, matched for age and sex. Results showed amplitude attenuation of EP events 100 msec poststimulus or later in the patients' EPs of all modalities and in most lead locations. Attenuation of later EP events thus appears to be a general characteristic of schizophrenia. Comparisons of chronic paranoid and undifferentiated with other patient subtypes revealed a relatively specific correlate of the chronic subgroup, increased negativity of a negative somatosensory peak occurring 60 msec poststimulus (N60) at contralateral central leads.
这是一份关于采用综合方法研究精神疾病患者诱发电位（EP）特征所获结果的初步报告。对32名精神分裂症患者和16名年龄及性别匹配的非患者，获取了针对左右正中神经、视觉（棋盘格闪光）及听觉（咔嗒声）刺激的诱发电位，在14个单极头皮部位和1个眼电图导联进行记录。结果显示，在所有模式的患者诱发电位中以及大多数导联位置，刺激后100毫秒及更晚的诱发电位事件出现波幅衰减。因此，后期诱发电位事件的衰减似乎是精神分裂症的一个普遍特征。将慢性偏执型和未分化型与其他患者亚型进行比较发现，慢性亚组存在一个相对特异的关联，即对侧中央导联在刺激后60毫秒出现的负性躯体感觉峰（N60）负性增强。
