Howe G B, Swettenham K V, Currey H L
Blood. 1980 Oct;56(4):696-700.
Most methods of measuring neutrophil motility provide information mainly about the performance of a small proportion of the fastest moving cells. Application of a computer-linked image analysis technique, using the "Quantimet," provides a convenient, automated method of measuring the motility of the whole cell population. This makes it possible to test whether changes in motility represent a homogeneous alteration affecting all cells or a change in the numbers or performance of a subset of cells. In this study the neutrophils from patients with uncomplicated rheumatoid arthritis were found to perform similarly to normals, while cells from patients with Felty's syndrome were markedly slower. This was an overall, homogeneous slowing of the whole cell population, not due to a loss of fast moving cells.
大多数测量中性粒细胞运动性的方法主要提供的是一小部分运动速度最快的细胞的表现信息。应用一种与计算机相连的图像分析技术，使用“定量图像分析仪”，可提供一种便捷、自动化的测量整个细胞群体运动性的方法。这使得能够测试运动性的变化是代表影响所有细胞的均匀改变，还是代表一部分细胞数量或表现的变化。在本研究中，发现无并发症类风湿关节炎患者的中性粒细胞表现与正常人相似，而费尔蒂综合征患者的细胞则明显较慢。这是整个细胞群体的总体、均匀减慢，并非由于快速运动细胞的减少。
