Tamai S, Kameya T, Shimosato Y, Tsumuraya M, Wada T
Cancer. 1980 Sep 15;46(6):1389-96. doi: 10.1002/1097-0142(19800915)46:6<1389::aid-cncr2820460617>3.0.co;2-d.
A pulmonary blastoma in a 52-year-old Japanese man was serially transplanted into athymic nude mice. This report emphasizes the characteristics of the neoplasm seen on light and electron microscopic examination. The original tumor consisted of branching tubular structures and primitive mesenchymal components with a few smooth-muscle cell bundles, and resembled fetal lung tissue. Electron microscopic examination revealed that the immature stromal cells resembled epithelial cells. After serial passages in nude mice, the stromal element of the tumor disappeared, and the epithelial element showed squamous metaplasia and occasional mucus production. Endocrine-type granules were observed in a few tumor cells. Histogenetic considerations, including a suggestion that the tumor was derived from entodermal cells, are presented.
一名52岁日本男性的肺母细胞瘤被连续移植到无胸腺裸鼠体内。本报告着重阐述了在光镜和电镜检查中所见肿瘤的特征。原发肿瘤由分支管状结构和原始间充质成分组成，伴有少量平滑肌细胞束，类似胎儿肺组织。电镜检查显示未成熟的基质细胞类似上皮细胞。在裸鼠体内连续传代后，肿瘤的基质成分消失，上皮成分出现鳞状化生并偶尔产生黏液。在少数肿瘤细胞中观察到内分泌型颗粒。文中还提出了组织发生学方面的考量，包括该肿瘤起源于内胚层细胞的推测。
