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先天性痉挛性偏瘫的产前起源

Prenatal origin of congenital spastic hemiparesis.

作者信息

Michaelis R, Rooschüz B, Dopper R

出版信息

Early Hum Dev. 1980 Sep;4(3):243-55. doi: 10.1016/0378-3782(80)90029-8.

DOI:10.1016/0378-3782(80)90029-8
PMID:7418636
Abstract

Using Prechtl's concept of optimal conditions, 13 out of 20 children suffering from congenital spastic hemiparesis presented reduced optimal obstetric and postnatal conditions which were within the 3rd and 80th percentiles of the reduced optimal conditions found in a population of 400 randomly selected newborns. In the 7 children with higher numbers of reduced optimal scores only items indicating perinatal asphyxia accounted for the higher risk. But no correlation could be found between the severity of handicap and perinatal complications. Therefore one may argue that newborns with prenatal cerebral lesions are more likely to suffer perinatal asphyxia, which does not necessarily cause a further damage to the brain. No specific peri- or postnatal complications could be found which would explain the origin of the hemiparesis in the 20 children. CAT-scan examinations in some children showed lesions of the gray or the white matter, but there were also scans without any abnormal findings at all. No correlation between the kind of cerebral lesion and the neurological findings could be drawn.

摘要

运用普雷茨尔的最佳条件概念,20名先天性痉挛性偏瘫患儿中有13名呈现出最佳产科和产后条件降低,这些条件处于从400名随机选取的新生儿群体中发现的降低的最佳条件的第3百分位和第80百分位之间。在7名最佳分数降低数量较多的患儿中,仅围产期窒息相关项目表明存在较高风险。但未发现残疾严重程度与围产期并发症之间存在关联。因此可以认为,患有产前脑损伤的新生儿更易遭受围产期窒息,而这不一定会对大脑造成进一步损伤。未发现能够解释这20名患儿偏瘫起源的特定围产期或产后并发症。部分患儿的计算机断层扫描(CAT)检查显示灰质或白质有病变,但也有扫描结果完全无异常发现的情况。无法得出脑损伤类型与神经学检查结果之间的关联。

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