接受血浆置换联合免疫抑制治疗的重症肌无力患者血清中的抗乙酰胆碱受体抗体滴度。
Anti-acetylcholine receptor antibody titres in the sera of myasthenia patients treated with plasma exchange combined with immunosuppressive therapy.
作者信息
Carter B, Harrison R, Lunt G G, Behan P O, Simpson J A
出版信息
J Neurol Neurosurg Psychiatry. 1980 May;43(5):397-402. doi: 10.1136/jnnp.43.5.397.
Abstract
Anti-acetylcholine receptor antibody titres have been monitored in the sera of 19 myasthenic patients treated with plasma exchange combined with a three month period of immunosuppressive therapy. In general the post-exchange titres stabilised at below pre-exchange levels for prolonged periods which were associated with clinical improvement. In seven instances recurrence of symptoms occurred and in six of these cases relapse was shown to be associated with a rise in anti-acetylcholine receptor antibody titre.
摘要
对19例接受血浆置换联合为期三个月免疫抑制治疗的重症肌无力患者的血清抗乙酰胆碱受体抗体滴度进行了监测。一般来说，置换后的抗体滴度在较长时间内稳定在低于置换前的水平，这与临床症状改善相关。有7例出现症状复发，其中6例复发被证明与抗乙酰胆碱受体抗体滴度升高有关。
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本文引用的文献
1
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Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value.重症肌无力中乙酰胆碱受体抗体。患病率、临床相关性及诊断价值。
Neurology. 1976 Nov;26(11):1054-9. doi: 10.1212/wnl.26.11.1054.
3
Plasmapheresis and immunosuppressive drug therapy in myasthenia gravis.重症肌无力的血浆置换和免疫抑制药物治疗
N Engl J Med. 1977 Nov 24;297(21):1134-40. doi: 10.1056/NEJM197711242972102.
4
5
Function of circulating antibody to acetylcholine receptor in myasthenia gravis: investigation by plasma exchange.重症肌无力中循环抗乙酰胆碱受体抗体的功能：通过血浆置换进行的研究
Neurology. 1978 Mar;28(3):266-72. doi: 10.1212/wnl.28.3.266.
6
alpha-Bungarotoxin and anti-acetylcholine receptor antibody binding to the human acetylcholine receptor.α-银环蛇毒素和抗乙酰胆碱受体抗体与人类乙酰胆碱受体的结合。
Adv Cytopharmacol. 1979;3:269-78.
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Muscle Nerve. 1978 Mar-Apr;1(2):151-6. doi: 10.1002/mus.880010208.
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9
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