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精神外科手术的伦理考量:前额叶白质切除术的不幸遗产。

Ethical considerations of psychosurgery: the unhappy legacy of the pre-frontal lobotomy.

作者信息

Gostin L O

出版信息

J Med Ethics. 1980 Sep;6(3):149-54. doi: 10.1136/jme.6.3.149.

Abstract

There is no subject at the interface of law, psychiatry and medical ethics which is more controversial than psychosurgery. The divergent views of the treatment begin with its definition. The World Health Organisation and others define psychosurgery as the selective surgical removal or destruction of nerve pathways or normal brain tissue with a view to influencing behaviour. However, proponents of psychosurgery demur on the basis that the modern' treatment is concerned predominantly with emotional illness, without any specific effect upon behaviour. The alternative definition offered is the surgical treatment of certain psychiatric illnesses by means of localised lesions placed in specific cerebral sites. It is difficult entirely to accept this definition because, as examined below, scientific psychiatry is not yet in a position to directly treat psychiatric illness solely through surgical intervention. There is no reliable theoretical relationship between particular cerebral sites (which are normal and healthy) and an identifiable psychiatric illness or symptomatology. Given this state of psychiatric understanding, it is misleading to suggest fine distinctions between generalised alteration of behaviour or mood and treatment of an illness. Highly divergent practices and theories (relating to the multiplicity of conditions treated, surgical methods adopted and areas of the brain operated upon) further undermine exaggerated claims that psychosurgery can scientifically treat' specific illness through precise surgical intervention. Nonetheless, contemporary psychosurgery does not contain quite the same broadbrush' approach of its ancestors and it can lay some legitimate claim as an effective empirical treatment in narrowly limited circumstances. Major ethical problems still, however, arise and these will be discussed in this article.

摘要

在法律、精神病学和医学伦理学的交叉领域,没有哪个主题比精神外科手术更具争议性。对于这种治疗方法的不同观点始于其定义。世界卫生组织和其他机构将精神外科手术定义为选择性地手术切除或破坏神经通路或正常脑组织,以期影响行为。然而,精神外科手术的支持者对此表示异议,他们认为“现代”治疗主要针对情感疾病,对行为没有任何特定影响。所提供的另一种定义是“通过在特定脑部位进行局部损伤来对某些精神疾病进行手术治疗”。很难完全接受这个定义,因为如下文所述,科学的精神病学尚未能够仅通过手术干预直接治疗精神疾病。特定的脑部位(这些部位是正常且健康的)与可识别的精神疾病或症状学之间不存在可靠的理论关系。鉴于精神病学的这种理解状态,在行为或情绪的普遍改变与疾病治疗之间进行细微区分是具有误导性的。高度不同的实践和理论(涉及所治疗病症的多样性、所采用的手术方法以及手术的脑区)进一步削弱了精神外科手术能够通过精确的手术干预科学地“治疗”特定疾病的夸大说法。尽管如此,当代精神外科手术并不包含与其前辈完全相同的“一刀切”方法,并且在极其有限的情况下,它可以作为一种有效的经验性治疗方法提出一些合理的主张。然而,主要的伦理问题仍然存在,本文将对此进行讨论。

本文引用的文献

1
Stereotactic amygdaloidotomy for aggressive behaviour.立体定向杏仁核切开术治疗攻击行为
J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):437-44. doi: 10.1136/jnnp.37.4.437.
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Letter: Stereotaxy for obesity.
Lancet. 1974 Feb 16;1(7851):267. doi: 10.1016/s0140-6736(74)92575-6.
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Psychosurgery: yesterday and today.
Br J Psychiatry. 1977 Sep;131:249-60. doi: 10.1192/bjp.131.3.249.

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