Gething M J, Bye J, Skehel J, Waterfield M
Nature. 1980 Sep 25;287(5780):301-6. doi: 10.1038/287301a0.
Double-stranded DNA copies of the RNA gene coding for the haemagglutinin glycoproteins from human H2 and H3 pandemic strains of influenza virus have been cloned. DNA sequence analysis provides the first reported complete nucleotide sequence of an H2 haemagglutinin gene and a partial sequence (45%) of the H3 gene. The H2 haemagglutinin gene consists of 1,773 nucleotides containing an uninterrupted coding sequence of 1,686 nucleotides specifying a protein of 562 amino acids. Comparison of the amino acid sequences of these haemagglutinins with those of other H3 and avian strains reveals the extent of sequence changes in antigenic shifts and drifts.
编码人源H2和H3流感大流行株血凝素糖蛋白的RNA基因的双链DNA拷贝已被克隆。DNA序列分析首次报道了H2血凝素基因的完整核苷酸序列和H3基因的部分序列（45%）。H2血凝素基因由1773个核苷酸组成，包含一个1686个核苷酸的不间断编码序列，指定一个由562个氨基酸组成的蛋白质。将这些血凝素的氨基酸序列与其他H3和禽流感株的氨基酸序列进行比较，揭示了抗原性转变和漂移中序列变化的程度。
