来自克隆DNA的流感病毒血凝素基因的完整核苷酸序列

Complete nucleotide sequence of an influenza virus haemagglutinin gene from cloned DNA.

作者信息

Porter A G, Barber C, Carey N H, Hallewell R A, Threlfall G, Emtage J S

出版信息

Nature. 1979 Nov 29;282(5738):471-7. doi: 10.1038/282471a0.

Abstract

A synthetic fowl plague virus (FPV) haemagglutinin gene has been cloned in bacteria and the complete sequence of the RNA gene deduced. It is 1,742 nucleotides long and the mRNA codes for 56.3 amino acids in an uninterrupted sequence. The nature of some of the important domains in the haemagglutinin has been established, and their structure is discussed in relation to their function. Extensive amino acid sequence homologies exist between FPV and human influenza haemagglutinins.

摘要

一种合成的禽痘病毒（FPV）血凝素基因已在细菌中克隆出来，并推导了该RNA基因的完整序列。它长1742个核苷酸，其信使核糖核酸（mRNA）连续编码563个氨基酸。已经确定了血凝素中一些重要结构域的性质，并结合其功能对它们的结构进行了讨论。禽痘病毒血凝素与人流感血凝素之间存在广泛的氨基酸序列同源性。