Käch O, Sturzenegger M H, Zbinden M A, Bucher U, Beck E A
Schweiz Med Wochenschr. 1980 Aug 23;110(34):1244-9.
In 310 individuals (165 men and 145 women) significant pathological processes were exluded by reference to the patient's history, by physical investigation and by detailed laboratory tests (clinical chemistry, hematological cytology and most important coagulation analyses). Hematological laboratory values were then evaluated for age and sex differences, and in women according to menstruation versus post-menopause an oral contraception. Only the well known sex-specific differences in hematocrit values, hemoglobin and red cell counts were statistically highly significant (Z > 10). All other hematological values were pooled after exclusion of methodological errors. According to the non-symmetrical distribution of hematological laboratory values, percentiles were calculated. The 2.5 to 97.5 percentiles thus established now serve as "normal hematological reference values" for our laboratory.
在310名个体（165名男性和145名女性）中，通过参考患者病史、体格检查以及详细的实验室检查（临床化学、血液学细胞学以及最重要的凝血分析）排除了显著的病理过程。随后评估血液学实验室值的年龄和性别差异，对于女性则根据月经状态与绝经后以及口服避孕药情况进行评估。只有血细胞比容值、血红蛋白和红细胞计数中众所周知的性别特异性差异在统计学上具有高度显著性（Z>10）。排除方法学误差后，所有其他血液学值进行了汇总。根据血液学实验室值的非对称分布，计算了百分位数。由此确定的2.5至97.5百分位数现在作为我们实验室的“正常血液学参考值”。
