Drouhet E, Dompmartin D, Papachristou-Moraiti A, Ravisse P
Sabouraudia. 1980 Jun;18(2):149-56.
An experimental dermatitis was established for the guinea pig and Swiss white mouse by topical application of cultures of Pityrosporum ovale, isolated from pityriasis capitis and from P. arbiculare isolated from pityriasis versicolor. Histology showed the development of the yeasts in the stratum corneum, with hyperkeratosis at the follicular ostium and in the pilous bulb: the clinical and histological appearances resembled human seborrheic dermatitis. The nude (nu/nu) mouse, the hair-less mouse and the nude rat were not susceptible to this experimental infection, probably because of the dystrophy of their pilous follicles and sebaceous glands. The experimental model permitted evaluation of antifungal agents. The Pityrosporum dermatitis disappeared rapidly after topical application of econazole or amphotericin B. No pathological differences were observed between the strains tested.
通过局部应用从头皮糠疹分离出的卵形糠秕孢子菌培养物以及从花斑糠疹分离出的微小糠秕孢子菌培养物，在豚鼠和瑞士小白鼠身上建立了实验性皮肤炎。组织学检查显示，酵母在角质层中生长，毛囊口和毛球处有角化过度：临床和组织学表现类似于人类脂溢性皮炎。裸鼠（nu/nu）、无毛小鼠和裸大鼠对这种实验性感染不敏感，可能是因为它们的毛囊和皮脂腺发育不良。该实验模型可用于评估抗真菌药物。局部应用益康唑或两性霉素B后，糠秕孢子菌性皮肤炎迅速消失。在所测试的菌株之间未观察到病理差异。
