Chesnokova N P, Alaeva I V, Astaf'eva O G
Vopr Med Khim. 1980 Sep-Oct;26(5):612-6.
Botulinic toxin inhibited oxygen utilization in fast, slow and mixed muscles during the paralytic step of general intoxication as well as in dynamics of local intoxication without any manifestations of hypoxic hypoxia. The data obtained suggest that the tissue hypoxia caused by botulinic toxin is not responsible for the primary impairment of innervation of the respiratory muscles and for insufficiency of the outer respiration.
肉毒毒素在全身中毒的麻痹阶段以及局部中毒动态过程中,对快肌、慢肌和混合肌的氧利用均有抑制作用,且无任何低氧性缺氧的表现。所获数据表明,肉毒毒素所致的组织缺氧并非呼吸肌神经支配原发性损害及外呼吸功能不全的原因。