Nilius B
Acta Biol Med Ger. 1980;39(2-3):243-54.
A numerical method is described suitable to reconstruct the repolarization phase of the action potential measured from the mammalian atrial myocardium. The method allows an estimation of the current-voltage relationship of a time-independent potassium outward current and a voltage- and time-dependent calcium current, an inactivation term of the calcium current and an estimation of the calcium and potassium amounts transported during the action potential. The numerical evaluation needs some pairs of voltage-time values obtained from the measured action potentials and the first time derivative of the action potential. An example of the method's usefulness is demonstrated. The described method is suitable to reconstruct the late repolarization phase of the atrial action potentials sufficiently.
描述了一种数值方法,适用于重构从哺乳动物心房心肌测量得到的动作电位的复极化阶段。该方法能够估计与时间无关的钾外向电流和与电压及时间相关的钙电流的电流-电压关系、钙电流的失活项,以及动作电位期间转运的钙和钾的量。数值评估需要从测量的动作电位获得的几对电压-时间值以及动作电位的一阶时间导数。展示了该方法实用性的一个例子。所描述的方法足以重构心房动作电位的晚期复极化阶段。