Kaur C, Mangat H K
Andrologia. 1980 Jul-Aug;12(4):373-8. doi: 10.1111/j.1439-0272.1980.tb00648.x.
A short term treatment of 14 days with estradiol dipropionate, ovocyclin¿ to adult male albino rats for 7 and 14 days in a dose of 2 mg/rat significantly inhibited the structural and functional integrity of the testis and accessory glands. The weights of these organs were significantly reduced. The activity of the enzymes acid and alkaline phosphatase and succinic dehydrogenase in testis and the concentration of sialic acids, fructose and citric acid in caput and cauda epididymides, prostate and seminal vesicles respectively were significantly lowered after both treatments. All these changes were found to be irreversible even on withdrawal of ovocyclin¿ for 28 days after 14 days treatment. On discussing the results with previous reports, it is proposed that estrogens probably impede the activity of these organs by inhibition of androgen production, their antiandrogenic nature or their direct action on these organs.
对成年雄性白化大鼠连续14天短期给予二丙酸雌二醇（环戊丙酸雌二醇），剂量为2毫克/只，分别给药7天和14天，显著抑制了睾丸和附属腺体的结构和功能完整性。这些器官的重量显著减轻。两种处理后，睾丸中酸性磷酸酶、碱性磷酸酶和琥珀酸脱氢酶的活性以及附睾头、附睾尾、前列腺和精囊中唾液酸、果糖和柠檬酸的浓度均显著降低。即使在14天治疗后停用环戊丙酸雌二醇28天，所有这些变化仍被发现是不可逆的。在将这些结果与先前的报告进行讨论时，有人提出雌激素可能通过抑制雄激素生成、其抗雄激素性质或对这些器官的直接作用来阻碍这些器官的活性。
