Shelat Suresh G, Chacosky Deborah, Shibutani Susan
Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Am J Clin Pathol. 2008 Jul;130(1):127-30. doi: 10.1309/E5R9P5YPHXFE3198.
The erythrocyte sedimentation rate (ESR) is a nonspecific screening test to assess elevations of acute phase proteins that occur in various acute and chronic diseases. The recommended method is based on the Westergren method. Other technologies to measure ESR have been developed, including centrifugation-based methods. We compared a centrifugation method (ESR STAT PLUS, Hema Technologies, Lebanon, NJ) with the current Westergren method (Sediplast ESR system, Polymedco, Cortlandt Manor, NY) at 3 ESR levels (0-20, 21-60, and >60 mm/h) in a pediatric population and found correlation coefficients of r=0.63, r=0.83, and r=0.43 respectively. The centrifugation ESR exceeded the Westergren ESR by a small but significant amount in the 0-20 mm/h range, where most normal ranges fall. The 2 methods were also compared in blood samples from patients with sickle cell disease, who tend to have lower ESRs owing to impaired rouleau formation. In the sickle cell group (n=39; r=0.87), the centrifugation ESR consistently exceeded (97% of time) the Westergren ESR. This study identifies the differences in ESR results using 2 methods in general and specific pediatric populations.
红细胞沉降率（ESR）是一种非特异性筛查试验，用于评估在各种急慢性疾病中出现的急性期蛋白升高情况。推荐方法基于魏氏法。已经开发出其他测量ESR的技术，包括基于离心的方法。我们在儿科人群中，于3个ESR水平（0 - 20、21 - 60和>60 mm/h）下，将一种离心法（ESR STAT PLUS，Hema Technologies，黎巴嫩，新泽西州）与当前的魏氏法（Sediplast ESR系统，Polymedco，科特兰特庄园，纽约州）进行比较，发现相关系数分别为r = 0.63、r = 0.83和r = 0.43。在0 - 20 mm/h范围内（大多数正常范围所在区间），离心法测得的ESR比魏氏法测得的ESR超出少量但有显著差异。还对镰状细胞病患者的血样进行了这两种方法的比较，由于缗钱状形成受损，这类患者的ESR往往较低。在镰状细胞病组（n = 39；r = 0.87）中，离心法测得的ESR始终超过（97%的时间）魏氏法测得的ESR。本研究确定了在一般和特定儿科人群中使用两种方法时ESR结果的差异。
