甲氨蝶呤浓度和暴露时间对体外培养的哺乳动物细胞存活的影响。
Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro.
作者信息
Eichholtz H, Trott K R
出版信息
Br J Cancer. 1980 Feb;41(2):277-84. doi: 10.1038/bjc.1980.40.
Abstract
Chinese hamster, HeLa and HAK cells were treated with methotrexate (MTX) to determine the dependence of its effect on drug concentration and exposure time. With a broad range of survival curves for Chinese hamster cells, cell survival is an exponential function of exposure time and a power function of drug concentration. The data allow a mathematical description to be made of the interdependence of MTX concentration and drug exposure in relation to cell survival.
摘要
用甲氨蝶呤（MTX）处理中国仓鼠、HeLa和HAK细胞，以确定其作用对药物浓度和暴露时间的依赖性。中国仓鼠细胞具有广泛的存活曲线，细胞存活是暴露时间的指数函数和药物浓度的幂函数。这些数据允许对甲氨蝶呤浓度与药物暴露在细胞存活方面的相互依赖性进行数学描述。
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