Fraser N C
Br Med J. 1980 Jun 28;280(6231):1595-8. doi: 10.1136/bmj.280.6231.1595.
In the 20 years 1958-77 598 deaths were registered as due to accidental poisoning in British children under the age of 10-343 boys and 255 girls. Drugs caused 484 deaths, non-medicinal products 111, and plants three. The annual number of deaths reached a peak in 1964 but fell steadily thereafter; 16 deaths occurred in 1977. After 1970 tricyclic antidepressants replaced salicylates as the most commonly fatal poison. The next ten drugs most often recorded in 1970-7 were, in order, opiates (including diphenoxylate/atropine (Lomotil)), barbiturates, digoxin, orphenadrine (Disipal), quinine, potassium, iron, fenfluramine (Ponderax), antihistamines, and phenothiazines. In 20 years paracetamol caused one death, and before 1976 deaths caused by aspirin had fallen to fewer than two a year. Thus the introduction in 1976 and 1977 of safety packaging of these drugs can be expected to have little impact on the mortality from them in childhood.
在1958年至1977年的20年间，英国登记了598例10岁以下儿童意外中毒死亡病例，其中男孩343例，女孩255例。药物导致484例死亡，非药品111例，植物3例。死亡人数在1964年达到峰值，此后稳步下降；1977年有16例死亡。1970年后，三环类抗抑郁药取代水杨酸盐成为最常见的致命毒药。1970年至1977年记录的接下来十种最常见药物依次为阿片类药物（包括地芬诺酯/阿托品（洛哌丁胺））、巴比妥类药物、地高辛、奥芬那君（地昔帕明）、奎宁、钾、铁、芬氟拉明（芬普雷司）、抗组胺药和吩噻嗪类药物。20年间，对乙酰氨基酚导致1例死亡，1976年前阿司匹林导致的死亡人数已降至每年不到2例。因此，预计1976年和1977年对这些药物采用安全包装对儿童期因这些药物导致的死亡率影响不大。
