Raw M, Jarvis M J, Feyerabend C, Russell M A
Br Med J. 1980 Aug 16;281(6238):481-2. doi: 10.1136/bmj.281.6238.481.
The results of using nicotine chewing-gum to treat dependent smokers attending a withdrawal clinic were compared with the results of psychological treatment. At one-year follow-up 26 (38%) out of 69 people who received nicotine gum were abstinent compared with seven (14%) out of 49 who received psychological treatment (p < 0.01). Abstinence was confirmed by the measurement of carboxyhaemoglobin concentrations or expired air carbon monoxide. Blood nicotine concentrations when patients used the gum averaged half the smoking values, and side effects were few. Addiction occurred in only two subjects. Thus nicotine chewing-gum is a useful aid to giving up smoking and is probably acceptable even for people with cardiovascular disease.
将使用尼古丁口香糖治疗在戒烟诊所就诊的吸烟成瘾者的结果与心理治疗的结果进行了比较。在一年的随访中，接受尼古丁口香糖治疗的69人中有26人（38%）戒烟，而接受心理治疗的49人中有7人（14%）戒烟（p<0.01）。通过测量碳氧血红蛋白浓度或呼出气体中的一氧化碳来确认戒烟情况。患者使用口香糖时的血液尼古丁浓度平均为吸烟时的一半，且副作用较少。仅两名受试者出现成瘾情况。因此，尼古丁口香糖是戒烟的一种有用辅助手段，甚至对于患有心血管疾病的人可能也是可以接受的。
