Russell M A, Jarvis M J, Feyerabend C, Fernö O
Br Med J (Clin Res Ed). 1983 Feb 26;286(6366):683-4. doi: 10.1136/bmj.286.6366.683.
A nasal solution was developed containing 2 mg nicotine for use as a kind of liquid snuff. Its absorption was studied in three subjects. An average peak of plasma nicotine concentrations of 86.9 nmol/l (14.1 ng/ml) was reached seven and a half minutes after taking the solution. This compared with an average peak of 158.4 nmol/l (25.7 ng/ml) one and a half minutes after completing (but seven and a half minutes after starting) a middle tar cigarette (1.4 mg nicotine) and an average peak of 52.4 nmol/l (8.5 ng/ml) after chewing nicotine gum (2 mg nicotine) for 30 minutes. The more rapid and efficient absorption of nicotine from the nasal nicotine solution than from nicotine chewing gum suggests that it might prove a useful aid to giving up smoking. Nasal nicotine solution might be particularly useful in smokers for whom the gum is less suitable on account of dentures or peptic ulcers or who experience nausea and dyspeptic symptoms from the gum.
一种含2毫克尼古丁的鼻腔溶液被开发出来用作一种液体鼻烟。在三名受试者身上研究了其吸收情况。服用该溶液后7分半钟，血浆尼古丁浓度平均峰值达到86.9纳摩尔/升（14.1纳克/毫升）。相比之下，吸完一支中焦油香烟（含1.4毫克尼古丁）后1分半钟（但开始吸烟后7分半钟）血浆尼古丁浓度平均峰值为158.4纳摩尔/升（25.7纳克/毫升），咀嚼尼古丁口香糖（2毫克尼古丁）30分钟后血浆尼古丁浓度平均峰值为52.4纳摩尔/升（8.5纳克/毫升）。与从尼古丁口香糖中吸收尼古丁相比，从鼻腔尼古丁溶液中吸收尼古丁更快且更有效，这表明它可能被证明是一种有助于戒烟的有用辅助手段。鼻腔尼古丁溶液对于因假牙或消化性溃疡而不太适合使用口香糖的吸烟者，或者因口香糖而出现恶心和消化不良症状的吸烟者可能特别有用。
