Fu T C, Halenda S P, Dewey W L
Brain Res. 1980 Nov 24;202(1):33-9. doi: 10.1016/0006-8993(80)90641-1.
Acupuncture analgesia was quantitated in the phenylquinone induced writhing test in mice. Both manual acupuncture and electroacupuncture significantly reduced the number of writhes, i.e. 47% and 51% reduction respectively. Naloxone (2 mg/kg) pretreatment abolished this antinocicpetive effect suggesting that an endogenous opiate-like substance was involved. Hypophysectomy did not alter the electroacupuncture induced inhibition of writhing. These results confirm previous reports that acupuncture causes the release of an endogenous substance(s) with opioid activity, but disagree with previous reports in that our data show that the hypophysis is not involved in the release of this endogenous opiate or in any other mechanism of acupuncture analgesia in the mouse.
在苯醌诱发的小鼠扭体试验中对针刺镇痛进行了定量研究。手针和电针均显著减少了扭体次数，即分别减少了47%和51%。纳洛酮（2毫克/千克）预处理消除了这种抗伤害感受作用，提示有内源性阿片样物质参与。垂体切除并未改变电针诱导的扭体抑制作用。这些结果证实了先前的报道，即针刺可导致具有阿片样活性的内源性物质释放，但与先前报道不同的是，我们的数据表明垂体并不参与这种内源性阿片的释放，也不参与小鼠针刺镇痛的任何其他机制。
