肥胖中的胆固醇和胆汁酸代谢
Cholesterol and bile acid metabolism in obesity.
作者信息
Leijd B
出版信息
Clin Sci (Lond). 1980 Sep;59(3):203-6. doi: 10.1042/cs0590203.
PMID:7428289
Abstract
- The present study was undertaken to determine the influence of obesity on bile acid kinetics and cholesterol balance in man. 2. Fourteen obese and normolipidaemic patients (160 +/- 6% of ideal body weight, mean +/- SEM) were studied under standardized dietary conditions. Bile acid kinetics, were determined with the aid of 14C-labelled cholic acid and chenodeoxycholic acid. Cholesterol balance was calculated as the sum of bile acid synthesis plus daily faecal excretion of neutral C27 steroids minus dietary intake of cholesterol. The results obtained were compared with previously published data on control subjects (n = 13). 3. The cholesterol balance was higher in the obese patients (2.61 +/- 0.27 mmol/day) than in the control subjects (1.78 +/- 0.22 mmol/day), owing to a higher excretion of neutral steroids. When expressed per kg of body weight the cholesterol balance was quite normal in the obese patients.
摘要
- 本研究旨在确定肥胖对人体胆汁酸动力学和胆固醇平衡的影响。2. 在标准化饮食条件下，对14名肥胖且血脂正常的患者（体重为理想体重的160±6%，均值±标准误）进行了研究。借助14C标记的胆酸和鹅去氧胆酸测定胆汁酸动力学。胆固醇平衡的计算方法为胆汁酸合成量加上中性C27类固醇的每日粪便排泄量减去膳食胆固醇摄入量。将所得结果与先前发表的关于对照受试者（n = 13）的数据进行比较。3. 由于中性类固醇排泄量较高，肥胖患者的胆固醇平衡（2.61±0.27 mmol/天）高于对照受试者（1.78±0.22 mmol/天）。按每千克体重计算时，肥胖患者的胆固醇平衡相当正常。
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