Narita N, Nakao K, Uchida N, Yamaguchi K, Okamoto S, Kitamura Y, Matsumoto K
Gan. 1980 Aug;71(4):501-6.
About 350 castrated male DS mice given testosterone propionate (TP, 100 micrograms/mouse/day) were grafted with androgen-dependent SC115 tumor or androgen-independent tumors (NHD with positive receptor; NHF with negative receptor). After 20 or 15 days, most of the developed tumors were excised and the mice were divided into 3 groups. TP injection was continued in one group and TP was stopped immediately or 20 days after the excision in the other groups. The cumulative 120-day mortality after transplantation of SC115 tumor into mice was significantly lower in the immediate androgen removal group (10%, 6/59) than in the androgen-injected group (59%, 51/87) or the delayed androgen removal group (42%, 19/45). The cumulative mortalities in mice with androgen-independent NHD and NHF tumors in the immediate androgen removal groups (97 and 91%, respectively) were similar to those in the androgen-injected groups (90 and 95%, respectively). All non-operated and TP-injected mice grafted with SC115 and androgen-independent tumor died due to the tumors within 50 and within 30 days after the transplantation, respectively. These findings suggest the usefulness of adjuvant endocrine therapy for preventing the recurrence of hormone-dependent tumors.
给大约350只接受丙酸睾酮（TP，100微克/小鼠/天）处理的去势雄性DS小鼠移植雄激素依赖性SC115肿瘤或雄激素非依赖性肿瘤（受体阳性的NHD；受体阴性的NHF）。20天或15天后，切除大多数已形成的肿瘤，并将小鼠分为3组。一组继续注射TP，其他组在切除肿瘤后立即或20天后停止注射TP。将SC115肿瘤移植到小鼠体内后，立即去除雄激素组的120天累积死亡率（10%，6/59）显著低于注射雄激素组（59%，51/87）或延迟去除雄激素组（42%，19/45）。立即去除雄激素组中患有雄激素非依赖性NHD和NHF肿瘤的小鼠的累积死亡率（分别为97%和91%）与注射雄激素组（分别为90%和95%）相似。所有移植了SC115和雄激素非依赖性肿瘤的未手术且注射TP的小鼠分别在移植后50天内和30天内因肿瘤死亡。这些发现表明辅助内分泌治疗对预防激素依赖性肿瘤复发有用。
