Nagatsu I, Karasawa N, Shimizu N
Arch Histol Jpn. 1978 Nov;41(5):439-51. doi: 10.1679/aohc1950.41.439.
In order to find any morphological changes that might occur in the accumulation of catecholamine synthesizing enzymes following ligation of the sciatic nerve, light and electron microscopic studies were made in segments both proximal and distal to the ligature of the rat sciatic nerve from the initial period up to 4 days. The earliest changes were observed in the larger myelinated nerve fibers at 0.5 and 1.0 mm segments distal and proximal to the ligature, while little if any changes occurred in smaller myelinated nerve fibers. The non-myelinated fibers showed an increased electron density of axons due to the increase in density of the matrix, increased numbers of microtubules and/or microfibriles and of vesicles and vacuoles of varying size in addition to the enlarged size of the axon. These types of changes in the non-myelinated fibers seem to be more marked in the proximal segments, and are probably responsible for the accumulation of axoplasm containing some enzymes.
为了发现坐骨神经结扎后儿茶酚胺合成酶积累过程中可能出现的任何形态学变化，对大鼠坐骨神经结扎部位近端和远端的节段进行了从初期到4天的光镜和电镜研究。最早的变化在结扎部位远端和近端0.5毫米及1.0毫米节段的较大有髓神经纤维中观察到，而较小的有髓神经纤维几乎没有变化。无髓纤维除轴突增大外，还表现为轴突电子密度增加，这是由于基质密度增加、微管和/或微纤维数量增加、不同大小的囊泡和液泡数量增加所致。无髓纤维的这些类型变化在近端节段似乎更为明显，可能是含有某些酶的轴浆积累的原因。
